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Why when you sleep matter more than how long
The Signal A preprint posted this month analyzed 227,860 nights of concurrent sleep and continuous glucose monitoring data across nearly 6,000 adults and found that sleep consistency -- not just sleep duration -- is one of the strongest behavioral predictors...
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The Long Game
The Signal: New guidelines that could redefine who gets treated for cardiovascular disease The American College of Cardiology and the American Heart Association released an updated guideline for managing dyslipidemia this past Thursday American Heart Association, the first major overhaul...
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The Anti-Aging Signal.. in a Common Vaccine?

A study published this week out of the USC Leonard Davis School of Gerontology found that adults over 70 who received the shingles vaccine showed measurably slower biological aging across multiple domains, including lower chronic inflammation, slower epigenetic aging, and better composite biological age scores, compared to unvaccinated peers. The sample was nearly 4,000 people drawn from a nationally representative U.S. cohort, and the effects held even after controlling for income, education, and underlying health status. The results were most pronounced within three years of vaccination, but slower aging persisted beyond that window. Here's what people are reacting to: a routine shot your doctor has been recommending for years appears to do something that no supplement company has figured out how to bottle.

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VO₂ is the new signal on the block

Here’s what people are reacting to: a wave of new coverage highlighting VO₂ max as one of the strongest predictors of longevity, with cardiologists calling it a “vital sign” that deserves more attention than cholesterol alone. The takeaway circulating online is simple: if you want to live longer, improve your aerobic fitness.

As our ResetRx advisor, Dr. Jacob Kelly, explains:

“Cardiovascular fitness predicts longevity and how long someone will live with better accuracy than almost any other metric. The VO₂ max is like a credit score for your heart and mitochondria.” Read more on Dr. Kelly's substack

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